Evidenze scientifiche

La solida rilevanza scientifica del dispositivo Papimi® per la Terapia Enerpulse® e della tecnologia alla base del suo funzionamento è testimoniata dalle numerose evidenze scientifiche presenti in letteratura. In continua progressione ed aggiornamento da oltre 30 anni tali pubblicazioni documentano un grande numero di studi preclinici e clinici randomizzati, prospettici, controllati ed in doppio cieco pubblicati su riviste medico-scientifiche di primaria rilevanza accademica e tecnica. Gran parte di queste pubblicazioni sono inoltre presenti nei database bibliografici PubMed e PEDro (quest’ultimo un valido riferimento per la Evidence Based Medicine).

Il seguente elenco riporta una selezione delle principali evidenze scientifiche presenti in letteratura riguardanti gli effetti terapeutici dei campi elettromagnetici pulsati e suddivise in base alle patologie trattate.


Patologie Osteoarticolari

  1. A study of the effects of Pulsed Electro-Magnetic Field Therapy with respect to serological grouping in rheumatoid arthritis. Ganguly KS, Sarkar AK, Datta AK, Rakshit A. National Institute for the Orthopaedically Handicapped (NIOH), Calcutta.
  2. A case of congenital pseudarthrosis of the tibia treated with Pulsing Electro-Magnetic Fields. 17-year follow-up. Ito H, Shirai Y, Gembun Y. Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan.
  3. A double-blind trial of the clinical effects of electro-magnetic fields in osteoarthritis. Trock DH, Bollet AJ, Dyer RH Jr, Fielding LP, Miner WK, Markoll R. Department of Medicine (Rheumatology), Danbury Hospital, CT 06810 USA.
  4. The effect of Pulsed Electro-Magnetic Fields in the treatment of osteoarthritis of the knee and cervical spine. Report of randomized, double blind, placebo controlled trials. Trock DH, Bollet AJ, Markoll R. Department of Medicine, Danbury Hospital. CT USA.
  5. Magnetic pulse treatment for knee osteoarthritis: a randomised, double-blind, placebo-controlled study. Pipitone N, Scott DL. Rheumatology Department, King's College Hospital (Dulwich, England).
  6. Electro-Magnetic fields for the treatment of osteoarthritis. Hulme J, Robinson V, DeBie R, Wells G, Judd M, Tugwell P. Cochrane Collaborating Center, Center for Global Health, Institute of Population Health - University of Ottawa, 1 Stewart Street, Ottawa, Ontario, Canada, K1N 6N5.
  7. Modification of osteoarthritis by Pulsed Electro-Magnetic Field-a morphological study. Ciombor DM, Aaron RK, Wang S, Simon B.; Department of Orthopaedics, Brown Medical School, Providence USA.
  8. Pulsed magnetic field therapy for osteoarthritis of the knee-a double-blind sham-controlled trial. Nicolakis P, Kollmitzer J, Crevenna R, Bittner C, Erdogmus CB, Nicolakis J. Department of Physical Medicine and Rehabilitation, AKH Wien, University of Vienna, Vienna, Austria.
  9. Therapeutic effects of pulsed magnetic fields on joint diseases Riva Sanseverino E, Vannini A, Castellacci P., Università di Bologna, Italy
  10. Terapia a segnali pulsati nella patologia degenerativa artrosica: nostra esperienza. D.Rizzitano, A. Gatti et al. Università degli Studi di Roma “Tor Vergata”. Cattedra di specializzazione in Anestesia e rianimazione.
  11. Low-amplitude, extremely low frequency magnetic fields for the treatment of osteoarthritic knees: a double- blind clinical study. Jacobson JI, Gorman R, Yamanashi WS, Saxena BB, Clayton L. Altern Ther Health Med. 2001 Sep-Oct;7(5):54-64, 66-9.


Rigenerazione cellulare

  1. Effect of external Pulsing Electro-Magnetic Fields on the healing of soft tissue. Glassman LS, McGrath MH, Bassett CA. Division of Plastic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY.
  2. Pulsing Electro-Magnetic field therapy in nerve regeneration: an experimental study in the cat. Orgel MG, O'Brien WJ, Murray HM.
  3. Effect of Pulsed Electro-Magnetic Fields (PEMF) on osteoblast-like cells. Satake T. Department of Oral Biochemistry, Kanagawa Dental College, Japan.
  4. The Effect of Pulsed Electromagnetic Fields on Secondary SkinWound Healing:An Experimental Study. Athanasios Athanasiou, Spiridon Karkambounas, Anna Batistatou, Efstathios Lykoudis, Afroditi Katsaraki, Theodora Kartsiouni, Apostolos  Papalois, and Angelos Evangelou

Circolazione sanguigna

  1. Microcirculatory effects of Pulsed Electro-Magnetic Fields. Smith TL, Wong-Gibbons D, Maultsby J. Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1070, USA.


Edemi

  1. Low frequency and low intensity Pulsed Electro-Magnetic Field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity. Selvam R, Ganesan K, Narayana Raju KV, Gangadharan AC, Manohar BM, Puvanakrishnan R. Department of Pharmacology and Toxicology, Madras Veterinary College, Vepery, Chennai, India.
  2. Protection against focal cerebral ischemia following exposure to a Pulsed Electro-Magnetic Field. Grant G, Cadossi R, Steinberg G. Department of Neurosurgery, Stanford University, California.


Fibromialgia

  1. Exposure to a specific pulsed low-frequency magnetic field: a double-blind placebo-controlled study of effects on pain ratings in rheumatoid arthritis and fibromyalgia patients. Lawson Health Research Institute, St. Joseph's Health Care, London, Ontario N6A 4V2.

Iperplasia prostatica benigna

  1. "Effects of pulsed electromagnetic fields on benign prostate hyperplasia". International urology and nephrology. Giannakopoulos, XK; Giotis, C; Karkabounas, SC; Verginadis, II; Simos, YV; Peschos, D; Evangelou, AM (2011).

Patologie Ossee

  1. Pseudarthrosis after lumbar spine fusion: nonoperative salvage with Pulsed Electro-Magnetic Fields. Simmons JW Jr, Mooney V, Thacker I. UTMB, Galveston, Texas, USA.
  2. Effects of static magnetic and Pulsed Electro-Magnetic Fields on bone healing. Darendeliler MA, Darendeliler A, Sinclair PM. Discipline of Orthodontics, Faculty of Dentistry, University of Sydney, Australia.
  3. Pulsed Electro-Magnetic Fields for the treatment of bone fractures. Satter Syed A, Islam MS, Rabbani KS, Talukder MS. Industrial Physics Division, BCSIR Laboratories, Dhaka, Blangladesh.
  4. Effects of pulsed magnetic energy on a microsurgically transferred vessel. Roland D, Ferder M, Kothuru R, Faierman T, Strauch B. Department of Plastic and Reconstructive Surgery at the Albert Einstein College of Medicine, Bronx, NY, USA.
  5. Exposure to pulsed magnetic fields enhances motor recovery in cats after spinal cord injury. Crowe MJ, Sun ZP, Battocletti JH, Macias MY, Pintar FA, Maiman DJ. Neuroscience Research Laboratories, The Clement J. Zablocki VA Medical Center, Milwaukee USA.
  6. Treatment of non-union of bone fractures by pulsing electro-magnetic fields. Hutchings J.
  7. Acceleration of fracture repair by electromagnetic fields: A surgically non‐invasive method. Bassett CA, Pawluk RJ, Pilla AA. Ann N Y Acad Sci. 1974;238:242-62.
  8. Augmentation of bone repair by inductively coupled electromagnetic fields. Bassett CA, Pawluk RJ, Pilla AA. Science. 1974 May 3;184(136):575-7.
  9. A Non‐Operative salvage of surgically‐resistant pseudoarthroses and non‐unions by pulsing electromagnetic fields. Bassett CA, Pilla AA, Pawluk RJ. Clin Orthop Relat Res. 1977 May;(124):128-43.
  10. Slow healing fractures: can they be prevented? (Results of electrical stimulation in fibular steotomies in rats and in diaphyseal fractures of the tibia in humans). Fontanesi G, Traina GC, Giancecchi F, Tartaglia I, Rotini R, Virgili B, Cadossi R, Ceccherelli G. Ital J Orthop Traumatol. 1986 Sep;12(3):371-85.
  11. Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits. Matsumoto H, Ochi M, Abiko Y, Hirose Y, Kaku T, Sakaguchi K. Clinical Oral Implants Research, Volume 11, Issue 4, pages 354–360, August 2000.
  12. Stimulation of Fracture Healing with Electromagnetic Fields of Extremely Low Frequency (EMF of ELF). Wahlstrom O. Clinical Orthopaedics & Related Research.Section III: Basic Science and Pathology.
  13. Bone density changes in osteoporosis-prone women exposed to pulsed electromagnetic fields (PEMFs). Tabrah F, Hoffmeier M, Gilbert F Jr, Batkin S, Bassett CA. J Bone Miner Res. 1990 May;5(5):437-42.
  14. Long-term pulsed electromagnetic field (PEMF) results in congenital pseudarthrosis. Bassett CA, Schink-Ascani M. Calcif Tissue Int. 1991 Sep;49(3):216-20.
  15. Use of electromagnetic fields in a spinal fusion. A rabbit model. Glazer PA, Heilmann MR, Lotz JC, Bradford DS. Spine (Phila Pa 1976). 1997 Oct 15;22(20):2351-6.


Piaghe ed Ematomi

  1. The influence of pulsed electrical stimulation on the wound healing of burned rat skin. Castillo E, Sumano H, Fortoul TI, Zepeda A. Department of Physiology and Pharmacology, School of Veterinary Medicine, National Autonomous University of Mexico.
  2. Effect of low frequency Pulsing Electro-Magnetic Fields on skin ulcers of venous origin in humans: a double-blind study. Ieran M, Zaffuto S, Bagnacani M, Annovi M, Moratti A, Cadossi R. Department of Medical Angiology, Ospedale S. Maria Nuova, Reggio Emilia, Italy.
  3. Pulsed Electro-Magnetic Fields in experimental cutaneous wound healing in rats. Patino O, Grana D, Bolgiani A, Prezzavento G, Mino J, Merlo A, Benaim F. Department of Postgraduate Reconstructive and Plastic.
  4. Effects of pulsed extremely-low- frequency magnetic fields on skin wounds in the rat. Ottani V, De Pasquale V, Govoni P, Franchi M, Zaniol P, Ruggeri A. Istituto di Anatomia Umana Normale, Bologna, Italy.
  5. Effects of magnetic fields on skin wound healing. Experimental study. [Article in Spanish] Patino O, Grana D, Bolgiani A, Prezzavento G, Mino J, Merlo A, Benaim F. Department of Postgraduate Reconstructive and Plastic Surgery, Universidad del Salvador and Fundacion del Quemado, Spain.
  6. Effects of Pulsed Electro-Magnetic Fields on rat skin metabolism. De Loecker W, Delport PH, Cheng N. Afdeling Biochemie, Katholieke Universiteit te Leuven, Belgium.
  7. Electrochemical therapy of pelvic pain: effects of Pulsed Electro-Magnetic Fields (PEMF) on tissue trauma. Jorgensen WA, Frome BM, Wallach C. International Pain Research Institute, Los Angeles, California.


Osteoporosi

  1. The effect of long-term pulsing electro-magnetic field stimulation on experimental osteoporosis of rats. Mishima S. Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  2. Pulsed Electro-Magnetic Fields prevent osteoporosis in an ovariectomized female rat model: a prostaglandin E2-associated process. Chang K, Chang WH. Department of Biomedical Engineering, Chung-Yuan Christian University, Chung-Li, Taiwan, Republic of China.
  3. Bone density changes in osteoporosis-prone women exposed to Pulsed Electro- Magnetic Fields (PEMFs). Tabrah F, Hoffmeier M, Gilbert F Jr, Batkin S, Bassett CA. University of Hawaii School of Medicine, Straub Clinic and Hospital, Honolulu.


Dolore

  1. Evaluation of electro-magnetic fields in the treatment of pain in patients with lumbar radiculopathy or the whiplash syndrome. Thuile Ch, Walzl M., International Society of Energy Medicine, Vienna, Austria.
  2. Pain management and electro-magnetic medicine. Ouellette EA., University of Miami School of Medicine, Department of Orthopaedics and Rehabilitation, Florida, USA.
  3. Electrochemical therapy of pelvic pain: effects of Pulsed Electro-Magnetic Fields (PEMF) on tissue trauma. Jorgensen WA, Frome BM, Wallach C. International Pain Research Institute, Los Angeles, California.
  4. Spine fusion for discogenic low back pain: outcomes in patients treated with or without Pulsed Electro-Magnetic Field stimulation. Marks RA. Richardson Orthopaedic Surgery, Texas 75080, USA.
  5. Pulsed magnetic field therapy in refractory neuropathic pain secondary to peripheral neuropathy: electrodiagnostic parameters-pilot study. Weintraub MI, Cole SP. New York Medical College, Briarcliff Manor, New York 10510, USA.
  6. Effects of Pulsed Magnetic Field Therapy (PEMF) in the Treatment of Chronic Pain - A Pilot Study. Lap YY, Tung LY. The Journal of The Hong Kong Physiotherapy Association, Vol.10.
  7. Electrochemical Therapy of Pelvic Pain: Effects of Pulsed Electromagnetic Fields (PEMF) on Tissue Trauma. William A.  Jorgensen, Buce M. Frome, Charles Wallach

Tendiniti

  1. Pulsed magnetic and electro-magnetic fields in experimental achilles tendonitis in the rat: a prospective randomized study. Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
  2. Pulsed Electro-Magnetic Field therapy of persistent rotator cuff tendinitis. A double-blind controlled assessment. Binder A, Parr G, Hazleman B, Fitton- Jackson S.
  3. The effect of Pulsed Electro-Magnetic Fields on flexor tendon healing in chickens. Robotti E, Zimbler AG, Kenna D, Grossman JA. Miami Children's Hospital, USA.
  4. Pulsed magnetic and electro-magnetic fields in experimental achilles tendonitis in the rat: a prospective randomized study. Lee EW, Maffulli N, Li CK, Chan KM. Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong

Ulcere

  1. A portable Pulsed Electro-Magnetic Field (PEMF) device to enhance healing of recalcitrant venous ulcers: a double-blind, placebo-controlled clinical trial. Ronald O. Perelman Department of Dermatology, New York University Medical Center, New York.
  2. Treatment of chronic varicose ulcers with Pulsed Electro-Magnetic Fields: a controlled pilot study. Department of Dermatology, Belfast City Hospital, United Kingdom.